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The magnitude of heart rate increase in clinical trials was generally small and not clinically significant for most participants

B12 is often added to IV therapy visits, and many patients schedule a B12 shot the week between their IV appointments

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Patients who are deficient in vitamin B12 may receive these shots to help with their chronic fatigue, difficulty losing weight, brain fog, and more

Key takeaways There is no quality scientific evidence to suggest that coffee enemas provide health benefits

We thank Melanie Klemond, Rosalind Franklin University of Medicine and Science for critically reading the manuscript